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Article

Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG.

The Journal of surgical research - 1 Jul 2012

Liu Heping, Zhang Ti, Chen Rong, McConkey David J, Ward John F, Curley Steven A

Abstract excerpt

BACKGROUND: 17-Allylamino-17-demethoxygeldanamycin (17-AAG) specifically targets heat shock protein (HSP)90 and inhibits its chaperoning functions for multiple kinases involved in cancer cell growth and survival. To select responsive patients, the molecular mechanisms underlying the sensitivity of cancer cells to 17-AAG must be elucidated. MATERIALS AND METHODS: We used cytotoxicity assays and Western blotting to...

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Identifiers

PMID: 22099584
DOI: 10.1016/j.jss.2011.09.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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