Article
Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.
Gastroenterology - 1 Jul 2016
Wörmann Sonja M, Song Liang, Ai Jiaoyu, Diakopoulos Kalliope N, Kurkowski Magdalena U, Görgülü Kivanc, Ruess Dietrich, Campbell Andrew, Doglioni Claudio, Jodrell Duncan, Neesse Albrecht, Demir Ihsan E, Karpathaki Angelica-Phaedra, Barenboim Maxim, Hagemann Thorsten, Rose-John Stefan, Sansom Owen, Schmid Roland M, Protti Maria P, Lesina Marina, Algül Hana
Abstract excerpt
BACKGROUND & AIMS: One treatment strategy for pancreatic ductal adenocarcinoma is to modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) is associated with progression of pancreatic and other solid tumors. We investigated whether loss of P53 function contributes to persistent activation of STAT3 and modification of the pancreatic...
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