Article
A bioengineered organotypic prostate model for the study of tumor microenvironment-induced immune cell activation.
Integrative biology : quantitative biosciences from nano to macro - 16 Oct 2020
Kerr Sheena C, Morgan Molly M, Gillette Amani A, Livingston Megan K, Lugo-Cintron Karina M, Favreau Peter F, Florek Logan, Johnson Brian P, Lang Joshua M, Skala Melissa C, Beebe David J
Abstract excerpt
The prostate tumor microenvironment (TME) is strongly immunosuppressive; it is largely driven by alteration in cell phenotypes (i.e. tumor-associated macrophages and exhausted cytotoxic T cells) that result in pro-tumorigenic conditions and tumor growth. A greater understanding into how these altered immune cell phenotypes are developed and could potentially be reversed would provide important insights into...
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