Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons.

doi:10.1093/sleep/zsaa211

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Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons.

Sleep - 12 Mar 2021

Khoury Samar, Wang Qiao-Ping, Parisien Marc, Gris Pavel, Bortsov Andrey V, Linnstaedt Sarah D, McLean Samuel A, Tungate Andrew S, Sofer Tamar, Lee Jiwon, Louie Tin, Redline Susan, Kaunisto Mari Anneli, Kalso Eija A, Munter Hans Markus, Nackley Andrea G, Slade Gary D, Smith Shad B, Zaykin Dmitri V, Fillingim Roger B, Ohrbach Richard, Greenspan Joel D, Maixner William, Neely G Gregory, Diatchenko Luda

Abstract excerpt

Poor sleep quality can have harmful health consequences. Although many aspects of sleep are heritable, the understandings of genetic factors involved in its physiology remain limited. Here, we performed a genome-wide association study (GWAS) using the Pittsburgh Sleep Quality Index (PSQI) in a multi-ethnic discovery cohort (n = 2868) and found two novel genome-wide loci on chromosomes 2 and 7 associated with...

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PMID: 33034629
DOI: 10.1093/sleep/zsaa211
PMCID: PMC7953222

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