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Article

ALK-positive compound Spitz nevus with extensive perineural and intraneural neurotropism.

Journal of cutaneous pathology - 1 Jan 2021

Brown Ryanne A, Wang Jennifer Y, Raghavan Shyam S, Zhang Jingjing, Wan Derrick C, Born Donald, Koo Matthew, Hazard Florette K, Novoa Roberto A, Rieger Kerri E

Abstract excerpt

Historically recognized by their characteristic histopathologic features, Spitz neoplasms are now known to be molecularly defined by mutually exclusive recurrent abnormalities that cause activation of the MAPK pathway. Spitz neoplasms with ALK rearrangements frequently demonstrate polypoid growth with a plexiform arrangement of nested, fusiform melanocytes in intersecting fascicles. Although neurotropism has been...

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Identifiers

PMID: 33034114
DOI: 10.1111/cup.13890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ALK-positive compound Spitz nevus with extensive perineural and intraneural neurotropism.PMID 33034114Read ↗

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