Article
Filigree-like Rete Ridges, Lobulated Nests, Rosette-like Structures, and Exaggerated Maturation Characterize Spitz Tumors With NTRK1 Fusion.
The American journal of surgical pathology - 1 Jun 2019
Yeh Iwei, Busam Klaus J, McCalmont Timothy H, LeBoit Philip E, Pissaloux Daniel, Alberti Laurent, de la Fouchardière Arnaud, Bastian Boris C
Abstract excerpt
Activating NTRK1 fusions have been described as oncogenic events across the spectrum of Spitz tumors. Herein we report a series of 38 Spitz tumors with NTRK1 fusion. These Spitz tumors have distinctive histopathologic features characterized by filigree-like rete ridges which are elongated, thin and branched, dermal melanocytes arranged in a rosette-like configuration, and marked diminishment of melanocyte size...
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