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Article

Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy.

Chemical communications (Cambridge, England) - 7 Nov 2020

Wang Yadi, Wang Yue, Qian Jiang, Pan Xiaohong, Li Xueling, Chen Feng, Hu Jun, Lü Junhong

Abstract excerpt

We conceptually demonstrate single-cell infrared phenomics as a novel strategy of phenotypic screening with infrared microspectroscopy. Based on this development, the cancer cell HepG2 glycocalyx was first identified as a potential target of protopanaxadiol, an herbal medicine. These findings provide a powerful tool to accurately evaluate the cell stress response and to largely expand the phenotypic screening...

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PMID: 33030170
DOI: 10.1039/d0cc05721e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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