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Article

The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels.

Cell chemical biology - 19 Jun 2025

Molina Irene, Mansell Ryan, Liang Rui, Crespo Benigno, Puente Margarita, Franco Virginia, Viera Sara, Camino Isabel, Saadeddin Anas, Bellotti Peter, Leung Annie, Henning Sam, Sun Shan, Herring Mikayla, Lopez Celia, Cuevas Carmen, Pogány Peter, Urones Beatriz, Baxt Leigh, Fernández Esther, Geri Jacob, Kirkman Laura, Kafsack Björn F C, Mata-Cantero Lydia

Abstract excerpt

Spreading resistance to front-line treatments necessitate the search for new classes of antimalarials. Limitations of standard screening conditions lead us to develop an assay using culture media that more closely reflects nutrient levels in human serum to reveal new therapeutically relevant parasite pathways. Our approach was validated by testing 22k compounds followed by a full 750k compound screen and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40412380
DOI: 10.1016/j.chembiol.2025.05.001
PMCID: PMC12181053

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