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Expression profiles of the SARS-CoV-2 host invasion genes in nasopharyngeal and oropharyngeal swabs of COVID-19 patients

1 Oct 2020

Abstract excerpt

We collect the nasopharyngeal and oropharyngeal swabs of 63 subjects with severe symptoms or contacts with COVID-19 confirmed cases to perform a pilot-study aimed to verify the "in situ" expression of SARS-CoV-2 host invasion genes ( ACE2 , TMPRSS2 , PCSK3 , EMILIN1 , EMILIN2 , MMRN1 , MMRN2 , DPP4 ). ACE2 (FC = +1.88, p ≤ 0.05) and DPP4 (FC = +3, p < 0.01) genes showed a significant overexpression in COVID-19...

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PMID: 33024851
DOI: 10.1016/j.heliyon.2020.e05143

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