Article

Enrichment of SARS-CoV-2 entry factors and interacting intracellular genes in peripheral immune cells

2021-03-29

Abstract excerpt

SARS-CoV-2 uses ACE2 and TMPRSS2 to gain entry into the cell. However, recent studies have shown that SARS-CoV-2 may use additional host factors that are required for the viral lifecycle. Here we used publicly available datasets, CoV associated genes and machine learning algorithms to explore the SARS-CoV-2 interaction landscape in different tissues. We find that in general a small fraction of cells expresses ACE2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78f4a7f7-c0e6-5101-85a1-f4c2ac9cee65
DOI: 10.1101/2021.03.29.437515

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enrichment of SARS-CoV-2 entry factors and interacting intracellular genes in peripheral immune cellsDOI 10.1101/2021.03.29.437515Read

SARS‐CoV ‐2 multifaceted interaction with the human host. Part II : Innate immunity response, immunopathology, and epigeneticsSemantic proximity Read

Distribution of ACE2, CD147, cyclophilins, CD26 and other SARS-CoV-2 associated molecules in human tissues and immune cells in health and diseaseSemantic proximity Read

Identifying Pathways and Networks Associated With the SARS-CoV-2 Cell Receptor ACE2 Based on Gene Expression Profiles in Normal and SARS-CoV-2-Infected Human TissuesSemantic proximity Read

Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19Semantic proximity Read

Comprehensive comparison of transcriptomes in SARS-CoV-2 infection: alternative entry routes and innate immune responsesSemantic proximity Read

ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19Semantic proximity Read

Immune interaction map of human SARS-CoV-2 target proteins: implications for therapeutic avenuesSemantic proximity Read

A Meta-analysis of Comorbidities in COVID-19: Which Diseases increase the Susceptibility of SARS-CoV-2 Infection?Semantic proximity Read

Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2.Semantic proximity Read

Multimodal single-cell omics analysis identifies epithelium–immune cell interactions and immune vulnerability associated with sex differences in COVID-19Semantic proximity Read

Secondary analysis of transcriptomes of SARS-CoV-2 infection models to characterize COVID-19Semantic proximity Read

SARS-CoV-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients by single-cell sequencingSemantic proximity Read