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SARS-CoV-2 Infection Boosts MX1 Antiviral Effector in COVID-19 Patients

23 Sept 2020

Abstract excerpt

In a published case-control study (GSE152075) from SARS-CoV-2-positive (n = 403) and -negative patients (n = 50), we analyzed the response to infection assessing gene expression of host cell receptors and antiviral proteins. The expression analysis associated with reported risk factors for COVID-19 was also assessed. SARS-CoV-2 cases had higher ACE2 , but lower TMPRSS2 , BSG/CD147, and CTSB expression compared...

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PMID: 32989429
DOI: 10.1016/j.isci.2020.101585

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