Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis

Abstract excerpt

BACKGROUND: Despite enormous efforts to combat malaria the disease still afflicts up to half a billion people each year of which more than one million die. Currently no approved vaccine is available and resistances to antimalarials are widely spread. Hence, new antimalarial drugs are urgently needed. RESULTS: Here, we present a computational analysis of the metabolism of Plasmodium falciparum, the deadliest...

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