Article
Analytical and clinical validation of pairwise microRNA expression analysis to identify medullary thyroid cancer in thyroid fine-needle aspiration samples.
Cancer cytopathology - 1 Mar 2021
Ciarletto Andrea M, Narick Christina, Malchoff Carl D, Massoll Nicole A, Labourier Emmanuel, Haugh Keith, Mireskandari Alidad, Finkelstein Sydney D, Kumar Gyanendra
Abstract excerpt
BACKGROUND: Medullary thyroid carcinoma (MTC) is an aggressive malignancy originating from the parafollicular C cells. Preoperatively, thyroid nodule fine-needle aspiration cytology (FNAC) and pathogenic gene mutations are definitive in approximately one-half of cases. MicroRNAs (miRNAs) are endogenous, noncoding, single-stranded RNAs that regulate gene expression, a characteristic that confers the potential for...
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