Article
Two-miRNA classifiers differentiate mutation-negative follicular thyroid carcinomas and follicular thyroid adenomas in fine needle aspirations with high specificity.
Endocrine - 1 Nov 2016
Stokowy Tomasz, Wojtas Bartosz, Jarzab Barbara, Krohn Knut, Fredman David, Dralle Henning, Musholt Thomas, Hauptmann Steffen, Lange Dariusz, Hegedüs László, Paschke Ralf, Eszlinger Markus
Abstract excerpt
Diagnosis of thyroid by fine needle aspiration is challenging for the "indeterminate" category and can be supported by molecular testing. We set out to identify miRNA markers that could be used in a diagnostic setting to improve the discrimination of mutation-negative indeterminate fine needle aspirations. miRNA high-throughput sequencing was performed for freshly frozen tissue samples of 19 RAS and PAX8/PPARG...
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