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Evaluating the clinical performance of an updated microRNA classifier in indeterminate and RAS-mutated thyroid nodule management: A multi-institutional study.

Surgery - 1 Jan 2025

Tumati Abhinay, Marshall Teagan E, Greenspun Benjamin, Chen Zhengming, Azar Sara Abou, Keutgen Xavier M, Laird Amanda M, Beninato Toni, Zarnegar Rasa, Fahey Thomas J, Finnerty Brendan M

Abstract excerpt

BACKGROUND: Integrating microRNA markers with next-generation sequencing panels may enhance risk assessment of cytologically indeterminate thyroid nodules. The ThyGeNEXT-ThyraMIRv1 multiplatform test version 1 demonstrated limited utility in risk-stratifying RAS-mutated indeterminate thyroid nodules. We sought to validate the updated ThyraMIRv2 platform in clinical practice. METHODS: ThyGeNEXT/ThyraMIRv2, a...

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PMID: 39394019
DOI: 10.1016/j.surg.2024.07.076

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