Article
MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility.
The Journal of clinical endocrinology and metabolism - 1 May 2008
Nikiforova Marina N, Tseng George C, Steward David, Diorio Donna, Nikiforov Yuri E
Abstract excerpt
OBJECTIVE: MicroRNA (miRNA) expression is deregulated in many types of human cancers. We sought to investigate the expression patterns of miRNA in all major types of thyroid tumors, including tumors carrying distinct oncogenic mutations, and to explore the utility of miRNA profiling for the preoperative diagnosis of thyroid nodules. DESIGN: miRNA expression levels were detected in 60 surgically removed thyroid...
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