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Article

Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells

24 Oct 2018

Abstract excerpt

Abstract The physiological importance of the interactions between hyaluronic acid (HA) and its main membrane receptor, CD44, in pathological processes, e.g. cancer, is well recognized. However, these interactions are mainly studied in solution, whereas HA in the extracellular matrix (ECM) is partially immobilized via its interactions with other ECM components. We therefore, developed substrates in which HA is...

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PMID: 30375477
DOI: 10.1038/s41598-018-34445-0

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