Article
The Membrane Transporter OAT7 (SLC22A9) Is Not a Susceptibility Factor for Osteoporosis in Europeans.
Frontiers in endocrinology - 1 Jan 2020
Nies Anne T, Weiss Stefan, Schaeffeler Elke, Hannemann Anke, Völker Uwe, Wallaschofski Henri, Schwab Matthias
Abstract excerpt
Bone production, maintenance, and modeling are a well-balanced process involving mineralization by osteoblasts and resorption by osteoclasts. Sex steroid hormones, including their conjugated forms, contribute majorly to maintaining this balance. Recently, variants in the SLC22A9 gene have been associated with osteoporosis in Korean females. We had recently shown that SLC22A9, encoding organic anion transporter 7...
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