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Article

Glycosylation of Trypanosoma cruzi TcI antigen reveals recognition by chagasic sera.

Scientific reports - 2 Oct 2020

Murphy Niamh, Rooney Barrie, Bhattacharyya Tapan, Triana-Chavez Omar, Krueger Anja, Haslam Stuart M, O'Rourke Victoria, Pańczuk Magdalena, Tsang Jemima, Bickford-Smith Jack, Gilman Robert H, Tetteh Kevin, Drakeley Chris, Smales C Mark, Miles Michael A

Abstract excerpt

Chagas disease is considered the most important parasitic disease in Latin America. The protozoan agent, Trypanosoma cruzi, comprises six genetic lineages, TcI-TcVI. Genotyping to link lineage(s) to severity of cardiomyopathy and gastrointestinal pathology is impeded by the sequestration and replication of T. cruzi in host tissues. We describe serology specific for TcI, the predominant lineage north of the...

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Identifiers

PMID: 33009443
DOI: 10.1038/s41598-020-73390-9
PMCID: PMC7532467

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