Article
Analysis of molecular diversity of the Trypanosoma cruzi trypomastigote small surface antigen reveals novel epitopes, evidence of positive selection and potential implications for lineage-specific serology.
International journal for parasitology - 1 Jul 2010
Bhattacharyya Tapan, Brooks Jessica, Yeo Matthew, Carrasco Hernan J, Lewis Michael D, Llewellyn Martin S, Miles Michael A
Abstract excerpt
Chagas disease, marked by life-long chronic infection with Trypanosoma cruzi, remains a major parasitic disease in Latin America. Genetically heterogeneous, T. cruzi is divided into six discrete typing units (DTUs), most recently grouped as TcI-VI. The trypomastigote small surface antigen (TSSA) of T. cruzi has been described as the only known serological marker to identify infection by TcII-VI, as distinct from...
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