Article
Computational Approaches to Accelerating Novel Medicine and Better Patient Care from Bedside to Benchtop.
Advances in protein chemistry and structural biology - 1 Jan 2016
Sakellaropoulos Theodore, Hur Junguk, Melas Ioannis N, Guo Ellen Y, Alexopoulos Leonidas, Bohlooly Mohammad, Bai Jane P F
Abstract excerpt
Some successes have been achieved in the war on cancer over the past 30 years with recent efforts on protein kinase inhibitors. Nonetheless, we are still facing challenges due to cancer evolution. Cancers are complex and heterogeneous due to primary and secondary mutations, with phenotypic and molecular heterogeneity manifested among patients of a cancer, and within an individual patient throughout the disease...
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