Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative pan-cancer analysis of MEK1 aberrations and the potential clinical implications.

Scientific reports - 15 Sept 2021

Zhou Zhiyang, Peng Bi, Li Juanni, Gao Kewa, Cai Yuan, Xu Zhijie, Yan Yuanliang

Abstract excerpt

Alterations of mitogen-activated protein kinase kinase 1 (MEK1) are commonly associated with tumorigenesis, and MEK1 is thought to be a suitable targeted therapy for various cancers. However, abnormal MEK1 alterations and their relevant clinical implications are unknown. Our research comprehensively analyzed the MEK1 alteration spectrum and provided novel insight for targeted therapies. There were 7694 samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to MAP Kinase Kinase 1
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 34526571
DOI: 10.1038/s41598-021-97840-0
PMCID: PMC8443600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative pan-cancer analysis of MEK1 aberrations and the potential clinical implications.PMID 34526571Read ↗

Integrative Pan-cancer Analysis of MEK1 Aberrations and the Potential Clinical ImplicationsSemantic proximity Read ↗

Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancerSemantic proximity Read ↗

Spectrum of BRAF Aberrations and Its Potential Clinical Implications: Insights From Integrative Pan-Cancer AnalysisSemantic proximity Read ↗

A mutational signature and significantly mutated driver genes associated with immune checkpoint inhibitor response across multiple cancers.Semantic proximity Read ↗

Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathwaysSemantic proximity Read ↗

Comprehensive molecular findings in primary malignant melanoma of the esophagus: A multicenter study.Semantic proximity Read ↗

Comprehensive genomic analysis of primary malignant melanoma of the esophagus reveals similar genetic patterns compared with epithelium-associated melanomas.Semantic proximity Read ↗

Response to MEK Inhibitor Therapy in MAP2K1 (MEK1) K57N Non-Small-Cell Lung Cancer and Genomic Landscape of MAP2K1 Mutations in Non-Small-Cell Lung Cancer.Semantic proximity Read ↗

A pancancer analysis of the clinical and genomic characteristics of multiple primary cancers.Semantic proximity Read ↗

Genomic landscape of cutaneous, acral, mucosal, and uveal melanoma in Japan: analysis of clinical comprehensive genomic profiling data.Semantic proximity Read ↗

High tumor mutational burden and PIK3CA mutations correlate with poor Merkel cell carcinoma-specific survival.Semantic proximity Read ↗

Deciphering the Complexity of MEK Mutations in the Clinic.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.