A lead candidate functional single nucleotide polymorphism within the WARS2 gene associated with waist-hip-ratio does not alter RNA stability.

doi:10.1016/j.bbagrm.2020.194640

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Article

A lead candidate functional single nucleotide polymorphism within the WARS2 gene associated with waist-hip-ratio does not alter RNA stability.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Nov 2020

Mušo Milan, Dumbell Rebecca, Pulit Sara, Sinnott-Armstrong Nasa, Laber Samantha, Zolkiewski Louisa, Bentley Liz, Claussnitzer Melina, Cox Roger D

Abstract excerpt

We have prioritised a single nucleotide polymorphism (SNP) rs2645294 as one candidate functional SNP in the TBX15-WARS2 waist-hip-ratio locus using posterior probability analysis. This SNP is located in the 3' untranslated region of the WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial) gene with which it has an expression quantitative trait in subcutaneous white adipose tissue. We show that transcripts of the...

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PMID: 33007465
DOI: 10.1016/j.bbagrm.2020.194640
PMCID: PMC7695619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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