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Article

Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis.

Scientific reports - 1 Oct 2020

Panach Layla, Pertusa Clara, Martínez-Rojas Beatriz, Acebrón Álvaro, Mifsut Damián, Tarín Juan J, Cano Antonio, García-Pérez Miguel Ángel

Abstract excerpt

To identify new candidate genes in osteoporosis, mainly involved in epigenetic mechanisms, we compared whole gene-expression in osteoblasts (OBs) obtained from women undergoing hip replacement surgery due to fragility fracture and severe osteoarthritis. Then, we analyzed the association of several SNPs with BMD in 1028 women. Microarray analysis yielded 2542 differentially expressed transcripts belonging to 1798...

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Identifiers

PMID: 33004909
DOI: 10.1038/s41598-020-72870-2
PMCID: PMC7530982

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