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Article

Transcriptional dysregulation of TRIM29 promotes colorectal cancer carcinogenesis via pyruvate kinase-mediated glucose metabolism.

Aging - 20 Jan 2021

Han Jing, Zhao Zitong, Zhang Nan, Yang Yang, Ma Liying, Feng Li, Zhang Xue, Zuo Jing, Fan Zhisong, Wang Yudong, Song Yongmei, Wang Guiying

Abstract excerpt

Targeted molecular therapy is the most effective treatment for cancer. An effective therapeutic target for colorectal cancer (CRC) is urgently needed. However, the mechanisms of CRC remain poorly understood, which has hampered research and development of CRC-targeted therapy. TRIM29 is a ubiquitin E3 ligase that has been reported as an oncogene in several human tumors. In this study, we show that increased levels...

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Identifiers

PMID: 33495406
DOI: 10.18632/aging.202414
PMCID: PMC7950264

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Transcriptional dysregulation of TRIM29 promotes colorectal cancer carcinogenesis via pyruvate kinase-mediated glucose metabolism.PMID 33495406Read ↗

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