Article
Predictive Role of TP53, PIK3CA and MLL2 in ER+ HER2+ Breast Bancer: Biomarker Analysis of Neo-ALL-IN [NCT 01275859].
Anticancer research - 1 Oct 2020
Park Ji Hyun, Ahn Jin-Hee, Kim Jeong Eun, Jung Kyung Hae, Gong Gyungyub, Lee Hee Jin, Son Byung-Ho, Ahn Sei-Hyun, Kim Hak-Hee, Shin Hee Jung, Moon Dae-Hyuk, Kim Deokhoon, Kim Sung-Bae
Abstract excerpt
BACKGROUND/AIM: Somatic mutations were investigated in 21 patients with postmenopausal estrogen receptor (ER)-positive and human epidermal growth factor receptor-2 (HER-2)-positive (ER+HER2+) breast cancer (BC) treated with neoadjuvant letrozole and lapatinib, to identify their distinct molecular landscape. PATIENTS AND METHODS: We used tissue samples of 21 patients from phase II Neo ALL-IN cohort, and somatic...
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