Article
Cutaneous T-cell lymphomas with pathogenic somatic mutations and absence of detectable clonal T-cell receptor gene rearrangement: two case reports.
Diagnostic pathology - 28 Sept 2020
Rojansky Rebecca, Fernandez-Pol Sebastian, Wang Erica, Rieger Kerri E, Novoa Roberto A, Zehnder James L, Kunder Christian A, Kim Youn H, Khodadoust Michael S, Brown Ryanne A
Abstract excerpt
BACKGROUND: Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of extranodal non-Hodgkin lymphomas for which diagnosis can be challenging given the potential for overlap with inflammatory dermatoses. Current diagnostic criteria for CTCL incorporate clinical and histopathologic findings as well as results of T-cell receptor (TCR) gene sequencing. Molecular interrogation of TCR genes, TRG and TRB, has...
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