Article
Single nucleotide polymorphisms and serologic levels of hypoxia-inducible factor1 α and vascular endothelial growth factor are associated with increased risk of oral submucous fibrosis in gutka users among a North Indian population.
Oral surgery, oral medicine, oral pathology and oral radiology - 1 Nov 2020
Gupta Shalini R, Sharma Alpana, Gupta Nidhi, Mani Kalaivani
Abstract excerpt
OBJECTIVES: Tissue hypoxia in oral submucous fibrosis (OSMF) induces hypoxia-inducible factor (HIF)-1 α and vascular endothelial growth factor (VEGF), causing angiogenesis. Single nucleotide polymorphisms (SNPs) may predict susceptibility to environmental carcinogens and to development of OSMF, as well as its severity and malignant transformation. This study aimed to determine the serologic levels and frequencies...
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