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Does Hypoxia-Inducible Factor -1 α (HIF-1α) C1772T polymorphism predict short-term prognosis in patients with oral squamous cell carcinoma (OSCC)?

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Aug 2018

Prasad Jitender, Goswami Binita, Gowda Srinivas H, Gupta Nikhil, Kumar Shilpa, Agarwal Kiran, Mehra Pravesh, Pahuja Bindiya K, Chauhan Anju

Abstract excerpt

BACKGROUND: Oral squamous cell carcinoma (OSCC) is a cancer of the oral cavity that is a major health problem in India. There is an urgent need to identify biomarkers that have prognostic significance. We studied HIF-1α levels as well as single-nucleotide polymorphism of HIF-1α gene in cancer and healthy controls. METHODS: Fifty newly diagnosed OSCC patients and 50 age and sex-matched healthy control were...

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PMID: 29675970
DOI: 10.1111/jop.12718

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