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HLA-G and HLA-F protein isoform expression in breast cancer patients receiving neoadjuvant treatment

25 Sept 2020

Abstract excerpt

The immunosuppressive human leukocyte antigens HLA-G and HLA-F are expressed on trophoblast and malignant cells. Four membrane-bound and three soluble HLA-G protein isoforms have been described, which have different immunosuppressive potentials. HLA-F has three transcript variants, resulting in three different protein isoforms. The aim of this study was to evaluate the prognostic and predictive value of HLA-G and...

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PMID: 32978482
DOI: 10.1038/s41598-020-72837-3

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