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Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer.

BMC cancer - 24 Mar 2021

Vitale Silvia R, Helmijr Jean A, Gerritsen Marjolein, Coban Hicret, van Dessel Lisanne F, Beije Nick, van der Vlugt-Daane Michelle, Vigneri Paolo, Sieuwerts Anieta M, Dits Natasja, van Royen Martin E, Jenster Guido, Sleijfer Stefan, Lolkema Martijn, Martens John W M, Jansen Maurice P H M

Abstract excerpt

BACKGROUND: Extracellular vesicles (EVs) are actively secreted by cells into body fluids and contain nucleic acids of the cells they originate from. The goal of this study was to detect circulating tumor-derived EVs (ctEVs) by mutant mRNA transcripts (EV-RNA) in plasma of patients with solid cancers and compare the occurrence of ctEVs with circulating tumor DNA (ctDNA) in cell-free DNA (cfDNA). METHODS: For this...

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Identifiers

PMID: 33761899
DOI: 10.1186/s12885-021-08007-z
PMCID: PMC7992353

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