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Extracellular vesicle-derived DNA for performing EGFR genotyping of NSCLC patients.

Molecular cancer - 27 Jan 2018

Hur Jae Young, Kim Hee Joung, Lee Jong Sik, Choi Chang-Min, Lee Jae Cheol, Jung Min Kyo, Pack Chan Gi, Lee Kye Young

Abstract excerpt

Tumor cells shed an abundance of extracellular vesicles (EVs) to body fluids containing bioactive molecules including DNA, RNA, and protein. Investigations in the field of tumor-derived EVs open a new horizon in understanding cancer biology and its potential as cancer biomarkers as well as platforms for personalized medicine. This study demonstrates that successfully isolated EVs from plasma and bronchoalveolar...

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Bronchoalveolar Lavage Fluid
Circulating Tumor DNA
DNA, Neoplasm
Drug Resistance, Neoplasm
Extracellular Vesicles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotyping Techniques

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Identifiers

PMID: 29374476
DOI: 10.1186/s12943-018-0772-6
PMCID: PMC5787306

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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