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Article

Replication and Genetic Risk Score Analysis for Pancreatic Cancer in a Diverse Multiethnic Population.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2020

Bogumil David, Conti David V, Sheng Xin, Xia Lucy, Shu Xiao-Ou, Pandol Stephen J, Blot William J, Zheng Wei, Le Marchand Loïc, Haiman Christopher A, Setiawan Veronica Wendy

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified several SNPs associated with pancreatic cancer. No studies yet have attempted to replicate these SNPs in US minority populations. We aimed to replicate the associations of 31 GWAS-identified SNPs with pancreatic cancer and build and test a polygenic risk score (PRS) for pancreatic cancer in an ethnically diverse population. METHODS: We evaluated...

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Identifiers

PMID: 32958499
DOI: 10.1158/1055-9965.EPI-20-0963
PMCID: PMC7710597

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