Article
Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction.
Journal of medical genetics - 1 Jun 2021
Galeotti Alice Alessandra, Gentiluomo Manuel, Rizzato Cosmeri, Obazee Ofure, Neoptolemos John P, Pasquali Claudio, Nentwich Michael, Cavestro Giulia Martina, Pezzilli Raffaele, Greenhalf William, Holleczek Bernd, Schroeder Cornelia, Schöttker Ben, Ivanauskas Audrius, Ginocchi Laura, Key Timothy J, Hegyi Péter, Archibugi Livia, Darvasi Erika, Basso Daniela, Sperti Cosimo, Bijlsma Maarten F, Palmieri Orazio, Hlavac Viktor, Talar-Wojnarowska Renata, Mohelnikova-Duchonova Beatrice, Hackert Thilo, Vashist Yogesh, Strouhal Ondrej, van Laarhoven Hanneke, Tavano Francesca, Lovecek Martin, Dervenis Christos, Izbéki Ferenc, Padoan Andrea, Małecka-Panas Ewa, Maiello Evaristo, Vanella Giuseppe, Capurso Gabriele, Izbicki Jakob R, Theodoropoulos George E, Jamroziak Krzysztof, Katzke Verena, Kaaks Rudolf, Mambrini Andrea, Papanikolaou Ioannis S, Szmola Richárd, Szentesi Andrea, Kupcinskas Juozas, Bursi Simona, Costello Eithne, Boggi Ugo, Milanetto Anna Caterina, Landi Stefano, Gazouli Maria, Vodickova Ludmila, Soucek Pavel, Gioffreda Domenica, Gemignani Federica, Brenner Hermann, Strobel Oliver, Büchler Markus, Vodicka Pavel, Paiella Salvatore, Canzian Federico, Campa Daniele
Abstract excerpt
BACKGROUND: Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed in advanced phases, resulting in very high mortality. Tools to identify individuals at high risk of developing PDAC would be useful to improve chances of early detection. OBJECTIVE: We generated a polygenic risk score (PRS) for PDAC risk prediction, combining the effect of...
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