Article
Exploring the Early Phase of Crohn's Disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Dec 2021
Bamias Giorgos, Cominelli Fabio
Abstract excerpt
The development of Crohn's disease (CD) is characterized by a breakdown of homeostatic immune-bacterial communication, which takes place at the intestinal mucosa when environmental triggers impact genetically predisposed individuals. Converging lines of evidence support the hypothesis that this pathogenetic model develops through sequential, although inter-related, steps that indicate failure of mucosal defense...
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