Article
Inflammatory bowel disease—from mechanisms to treatment strategies.
Autoimmunity - 1 Nov 2010
Melgar Silvia, Shanahan Fergus
Abstract excerpt
The inflammatory bowel diseases ulcerative colitis and Crohn's disease (CD) are heterogeneous syndromes representing the outcome of the colliding influences of shared and distinct genetic risk factors, environmental or lifestyle modifiers and immune effector mechanisms. Identification of specific genetic risk factors has provided a glimpse of potential pathways of tissue damage. Defective mucosal clearance of...
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