Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease.

Abstract excerpt

Crohn's disease aetiology is multifactorial and remains enigmatic. However, animal models show that disease heterogeneity is probable, in that more than one defective mucosal mechanism can produce the same clinical phenotype. For example, Crohn's-like lesions are reported after compromise of mucosal integrity per se in the presence of an intact immune system, through altered expression of mucosal adhesion...

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