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Article

Foxl2 is required for commitment to ovary differentiation

8 Jun 2005

Abstract excerpt

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 15944199
DOI: 10.1093/hmg/ddi210

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Foxl2 is required for commitment to ovary differentiationPMID 15944199Read ↗

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