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Article

Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development

31 Mar 2004

Abstract excerpt

FOXL2 mutations cause gonadal dysgenesis or premature ovarian failure (POF) in women, as well as eyelid/forehead dysmorphology in both sexes (the 'blepharophimosis-ptosis-epicanthus inversus syndrome', BPES). Here we report that mice lacking Foxl2 recapitulate relevant features of human BPES: males and females are small and show distinctive craniofacial morphology with upper eyelids absent. Furthermore, in mice...

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Identifiers

PMID: 15056605
DOI: 10.1093/hmg/ddh124

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