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Article

Chloroquine Sensitizes GNAQ/11-mutated Melanoma to MEK1/2 Inhibition.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2020

Truong Amanda, Yoo Jae Hyuk, Scherzer Michael T, Sanchez John Michael S, Dale Kali J, Kinsey Conan G, Richards Jackson R, Shin Donghan, Ghazi Phaedra C, Onken Michael D, Blumer Kendall J, Odelberg Shannon J, McMahon Martin

Abstract excerpt

PURPOSE: Mutational activation of GNAQ or GNA11 (GNAQ/11), detected in >90% of uveal melanomas, leads to constitutive activation of oncogenic pathways, including MAPK and YAP. To date, chemo- or pathway-targeted therapies, either alone or in combination, have proven ineffective in the treatment of patients with metastatic uveal melanoma. EXPERIMENTAL DESIGN: We tested the efficacy of chloroquine or...

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Identifiers

PMID: 32933997
DOI: 10.1158/1078-0432.CCR-20-1675
PMCID: PMC7710560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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