Article
Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib.
Autophagy - 1 Jun 2014
Goodall Megan L, Wang Tong, Martin Katie R, Kortus Matthew G, Kauffman Audra L, Trent Jeffrey M, Gately Stephen, MacKeigan Jeffrey P
Abstract excerpt
Autophagy is a dynamic cell survival mechanism by which a double-membrane vesicle, or autophagosome, sequesters portions of the cytosol for delivery to the lysosome for recycling. This process can be inhibited using the antimalarial agent chloroquine (CQ), which impairs lysosomal function and prevents autophagosome turnover. Despite its activity, CQ is a relatively inadequate inhibitor that requires high...
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