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Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway

15 Sept 2020

Abstract excerpt

BACKGROUND: Elderly populations are susceptible to critical limb ischemia (CLI), but conventional treatments cannot significantly decrease amputation and mortality. Although exercise is an effective "non-pharmacological medicine" targeting mitochondria to improve skeletal muscle function, few studies have focused on the application of exercise in CLI. METHODS: Elderly male C57BL/6 mice (14 months old) were used...

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PMID: 32933582
DOI: 10.1186/s13395-020-00245-2

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