Article

Involvement of TRPC6/NFAT Axis and Mitochondrial Quality Control in the Protective Effect of Aerobic Exercise against Doxorubicin-Induced Cardiomyopathy

2026-08-06

Abstract excerpt

<title>Abstract</title> <p>Doxorubicin (DOX), a common chemotherapeutic agent, leads to irreversible anthracycline-induced cardiomyopathy (AIC). Impaired mitochondrial quality control serves as a central pathogenic driver of AIC. Meanwhile, DOX provokes sustained overactivation of the TRPC6/NFAT cascade, generating self-amplifying excitation-transcription feedback within injured cardiomyocytes. Despite the well-d...

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Literature Corpus work: d81844bb-829d-5786-a1f8-fd91ae52daf0
DOI: 10.21203/rs.3.rs-10330057/v1

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