Article

Drp1-FGF21 axis drives FAPs-mediated fibro-adipogenic degeneration in Duchenne muscular dystrophy

2026-03-08

Abstract excerpt

<title>Abstract</title> <p>Mitochondrial dysfunction is an early pathogenic event in dystrophic muscle contributing to muscle damage. Here, we provide an in-depth characterization of the marked induction of mitochondrial fission in mdx muscle fibers, driven by excessive activation of the fission regulator Drp1. This aberrant Drp1 activity triggers the integrated stress response (ISR), resulting in muscle-derived...

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Literature Corpus work: 3fcec6c7-83c0-5576-81d9-40e7e1fafa37
DOI: 10.21203/rs.3.rs-8926306/v1

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