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Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases

8 Sept 2020

Abstract excerpt

DNA damage repair (DDR) mechanisms have been implicated in a number of neurodegenerative diseases (both genetically determined and sporadic). Consistent with this, recent genome-wide association studies in Huntington's disease (HD) and other trinucleotide repeat expansion diseases have highlighted genes involved in DDR mechanisms as modifiers for age of onset, rate of progression and somatic instability. At least...

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PMID: 32925081
DOI: 10.3233/jhd-200421

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