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Article

The NS2B-PP1α-eIF2α axis: Inhibiting stress granule formation and Boosting Zika virus replication

27 Jun 2024

Abstract excerpt

Stress granules (SGs), formed by untranslated messenger ribonucleoproteins (mRNPs) during cellular stress in eukaryotes, have been linked to flavivirus interference without clear understanding. This study reveals the role of Zika virus (ZIKV) NS2B as a scaffold protein mediating interaction between protein phosphatase 1α (PP1α) and eukaryotic initiation factor 2α (eIF2α). This interaction promotes eIF2α...

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PMID: 38935808
DOI: 10.1371/journal.ppat.1012355

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