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Article

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2016

Dong Xiaonan, Cheng Adam, Zou Zhongju, Yang Yih-Sheng, Sumpter Rhea M, Huang Chou-Long, Bhagat Govind, Virgin Herbert W, Lira Sergio A, Levine Beth

Abstract excerpt

The ubiquitin-proteasome system degrades viral oncoproteins and other microbial virulence factors; however, the role of endolysosomal degradation pathways in these processes is unclear. Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma, and a constitutively active viral G protein-coupled receptor (vGPCR) contributes to the pathogenesis of KSHV-induced tumors. We report that...

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Identifiers

PMID: 26929373
DOI: 10.1073/pnas.1601860113
PMCID: PMC4801257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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