Article
Shorter telomere length, higher telomerase activity in association with tankyrase gene polymorphism contribute to high-altitude pulmonary edema.
Human molecular genetics - 4 Nov 2020
Miglani Manjula, Rain Manjari, Pasha Qadar, Raj V Samuel, Thinlas Tashi, Mohammad Ghulam, Gupta Archana, Pandey Ramendra Pati, Vibhuti Arpana
Abstract excerpt
High-altitude pulmonary edema (HAPE) is a noncardiogenic form of pulmonary edema, which is induced upon exposure to hypobaric hypoxia at high altitude (HA). Hypobaric hypoxia generates reactive oxygen species that may damage telomeres and disturb normal physiological processes. Telomere complex comprises of multiple proteins, of which, tankyrase (TNKS) is actively involved in DNA damage repairs. We hence...
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