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Article

A novel algorithm comprehensively characterizes human RH genes using whole-genome sequencing data.

Blood advances - 22 Sept 2020

Chang Ti-Cheng, Haupfear Kelly M, Yu Jing, Rampersaud Evadnie, Sheehan Vivien A, Flanagan Jonathan M, Hankins Jane S, Weiss Mitchell J, Wu Gang, Vege Sunitha, Westhoff Connie M, Chou Stella T, Zheng Yan

Abstract excerpt

RHD and RHCE genes encode Rh blood group antigens and exhibit extensive single-nucleotide polymorphisms and chromosome structural changes in patients with sickle cell disease (SCD). RH variation can drive loss of antigen epitopes or expression of new epitopes, predisposing patients with SCD to Rh alloimmunization. Serologic antigen typing is limited to common Rh antigens, necessitating a genetic approach to...

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Identifiers

PMID: 32915977
DOI: 10.1182/bloodadvances.2020002148
PMCID: PMC7509869

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