Article
Bridging the Gap: High-Resolution RHCE Genotyping by Third-Generation Sequencing Enhances Serological Interpretation of Weak Variants.
Human mutation - 1 Jan 2026
Wu Fan, Sun Li-Yan, Liang Shuang
Abstract excerpt
From January 2022 to June 2023, this study enrolled 124 healthy blood donors. Column agglutination and third-generation sequencing (TGS) were used for RHCE genotyping and RhCE antigen typing. Additional serological screening was performed using conventional tube and column agglutination methods. Sanger sequencing was performed on 22 specimens with abnormal RhCE expression. Among the 124 samples, 102 exhibited...
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